STAT 179 - Introduction to Survival Analysis
Course Description
Topics to be discussed in this course include: basic quantities for survival
data, nonparametric inferences for basic survival quantities, semiparametric
proportional hazards model, inferences for parametric regression models.
Course Learning Outcomes
After completion of the course, the student should be able to:
- Demonstrate understanding of the basic concepts of survival data;
- Utilize the different statistical inferences useful only for time - to - event data;
- Apply statistical techniques appropriate only for survival data using statistical software ;
- Perform survival analysis on time – to – event data that occur in different fields
Course Outline
UNIT 1. INTRODUCTION
- Why Study Survival Analysis?
- Examples of survival data
UNIT 2. BASIC QUANTITIES AND MODELS
- The Survival Function
- The Hazard Function
- The Mean Residual Life Function and Median Life
- Common Parametric Models for Survival Data
UNIT 3. CENSORING AND TRUNCATION
- Right Censoring
- Left Censoring
- Interval Censoring
- Likelihood Construction for Censored Data
UNIT 4. NONPARAMETRIC ESTIMATION OF BASIC QUANTITIES
- Estimators of Survival and Cumulative Hazards Functions for Right Censored Data
- Pointwise Confidence for Survival Function
- Confidence Bands for the Survival
UNIT 5. HYPOTHESIS TESTING
- One Sample Test with Right Censored Data
- Tests for Two or More Sample
- Stratified Tests
- Renyi Type Tests
UNIT 6. SEMIPARAMETRIC PROPORTIONAL HAZARDS
- Partial Likelihoods for Distinct – Event Time Date
- Local Tests
- Model Building Using the Proportional Hazards Model
UNIT 7. REGRESSION DIAGNOSTICS
- Cox – Snell Residuals for Assessing the Fit of a Cox Model
- Graphical Checks of the Proportional Hazards Assumption
UNIT 8. INFERENCE FOR PARAMETRIC REGRESSION MODELS
- Weibull Distribution
- Log Logistic Distribution